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-synuclein, which happens to be a most important part of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, and that is an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) stress, suggest that dysfunction of the intracellular proteinase programs, for example ubiquitin-proteasome process or lysosomal program, which removes unneede
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